Description / mouse TRAIL protein
TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.
More Information
| Size | 50 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Assay#1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml. Assay#2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 174 |
| Molecular Weight | 20 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN |
| Synonyms | Tnfsf10; TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik |
| Uniprot ID | P50592 |
| Protein RefSeq | NP_033451.1 |
| mRNA RefSeq | NM_009425 |