Description / anti-human TNFSF18 (GITR Ligand) monoclonal antibody
GITR Ligand (GITRL) is a member of the TNF superfamily and has been designated TNFSF18. The carboxy-terminal extracellular domain shows sequence similarily to TNF-alpha/TNFSF1A, Fas Ligand/TNFSF6, TRAIL/TNFSF10, and TNF-beta/TNFSF1B. GITRL is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#4Q25) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of TNFSF18 extracellular domain (also called GITR ligand). |
| Antigen | Human recombinant TNFSF18 EC domain |
| Application | FC, N, Detection Ab |
| Synonyms | TNFSF18; TL6; AITRL; GITRL; hGITRL |
| Uniprot ID | Q9UNG2 |
| Protein RefSeq | NP_005083.2 |
| mRNA RefSeq | NM_005092.3 |