Description / anti-mouse TIE-2, agonistic monoclonal antibody
Tie-2 is an endothelial-specific receptor tyrosine kinase and a receptor for angiopoietins. Tie-2 is predominantly expressed in the endothelium and it is likely involved in the regulation of vascular maturation and stability.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG1 |
| Biological Activity | WB: 1:500-1000 |
| Clone Nr. | (#MAB1201) |
| Species Reactivity | Cross reactivity to other species has not been tested! |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse extracellular domain of Tie2 receptor. The IgG fraction of culture supernatant was purified by Protein G affinity chromatography an |
| Antigen | Mouse Tie2 extracellular domain |
| Application | WB, Activation |
| Synonyms | Angiopoietin-1 receptor; Endothelial tyrosine kinase; HYK; STK1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; p140 TEK; CD202b; Te |
| Uniprot ID | Q02858 |
| Protein RefSeq | NP_038718.2 |
| mRNA RefSeq | NM_013690.2 |