Description / human TFF-3 protein
The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation. Recombinant human TFF3 is a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
More Information
| Size | 5 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 μg/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 59 |
| Molecular Weight | 13.2 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF |
| Synonyms | TFF3; ITF; P1B; TFI |
| Uniprot ID | Q07654 |
| Protein RefSeq | NP_0031217.3 |
| mRNA RefSeq | NM_003226 |