Description / anti-mouse T-cell Immunoglobulin Mucin-2 (TIM-2) monoclonal antibody
TIM-2 is a type I membrane protein and is a member of the TIM protein family. TIM-2 has an immunoglobulin variable region-like domain followed by a mucin-like domain in its extracellular region.This protein family is characterized by their conserved immunoglobulin and mucin domains, as well as by their expression on activated T cells. TIM-2 is a receptor for Semaphorin 4A, which is expressed on dendritic cells and B cells. Semaphorin 4A has been shown to enhance T cell activation.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#5B23) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant TIM-2. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. |
| Antigen | mouse recombinant protein of TIM-2 |
| Application | WB, IHC (P) |
| Synonyms | Timd2; G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662 |
| Uniprot ID | Q8R183 |
| Protein RefSeq | NP_599010.4 |
| mRNA RefSeq | NM_134249.5 |