Description / bovine SRY protein
The „Sex determining region of Y-Gen” (SRY), known as SRY gene, is coding for a transkription factor (TDF for Testis-determining factor). It belongs to the protein family of DNA binding-proteins. The SRY gene is beside other genes used for the determination of the sex in human as well as other mammals. Most mammals have for this purpose a further gene, UBE1. In humans SRY is normally located on the short arm of the Y chromosome. Accordingly, people who possess this chromosome with the corresponding gene, normally have a male phenotype. It does not matter how many copies of the X chromosome are present, even people with a multiple X chromosome (Klinefelter's syndrome) have this. The protein encoded by the gene Testis-determining factor controls the development of male sex
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| Size | 10 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Data not available. |
| N Terminal Sequence | MFRVLN |
| Purity Confirmation | > 90% by SDS-PAGE |
| Length [aa] | 231 |
| Molecular Weight | 26.8 kDa |
| Species Reactivity | Bovine |
| Formulation | lyophilized |
| Buffer | water |
| Protein Sequence | MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPCNKSLEPGLSCAYFQYLE |
| Reconstitution | Centrifuge vial prior to opening. Bovine SRY should be reconstituted in PBS to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffered solutions. |
| Stability and Storage | The lyophilized powder although stable at room temperature for 3 weeks, is best stored desiccated at -20°C. Reconstituted bo SRY should be stored in working aliquots at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or B |
| Synonyms | Sex-determining region Y protein; Testis-determining factor |
| Uniprot ID | Q03255 |
| Protein RefSeq | NP_001014407.1 |
| mRNA RefSeq | NM_001014385.1 |