Description / anti-mouse Sclerostin monoclonal antibody
SOST, also known as sclerostin, is a member of the Cerberus/DAN family of BMP antagonists, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#4D77) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant Sclerostin. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. |
| Antigen | mouse recombinant protein of Sclerostin |
| Application | WB |
| Synonyms | Sost; 5430411E23Rik |
| Uniprot ID | Q99P68 |
| Protein RefSeq | NP_077769.3 |
| mRNA RefSeq | NM_024449.5 |