Description / human SCGF-alpha protein
Stem Cell Growth Factor-alpha (SCGF-alpha) is a newly discovered hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. Human SCGF-alpha is a non-glycosilated species-specific cytokine that can support growth of primitive hematopoietic cells, and in combination of EPO or GM-CSF, it promotes proliferation of erythroid and myeloid progenitors, respectively. Recombinant human SCGF-alpha is a 33.9 kDa polypeptide containing 305 amino acid residues.
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| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its inhibitory effect on the proliferation of TF-1 cells previously grown in media containing GM-CSF. The ED50 for this effect was observed at 2.5 ng/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 305 |
| Molecular Weight | 33.9 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | GHGARGAERE WEGGWGGAQE EEREREALML KHLQEALGLP AGRGDENPAG TVEGKEDWEM EEDQGEEEEE EATPTPSSGP SPSPTPEDIV TYILGRLAGL DAGLHQLHVR LHALDTRVVE LTQGLRQLRN AAGDTRDAVQ ALQEAQGRAE REHGRLEGCL KGLRLGHKCF LLSRDFEAQA AAQARCTARG GSLAQPADRQ QMEALTRYLR AALAPYNWPV WLGVHDRRAE GL |
| Synonyms | CLEC11A; P47; SCGF; LSLCL; CLECSF3 |
| Uniprot ID | Q9Y240 |
| Protein RefSeq | NP_002966.1 |
| mRNA RefSeq | NM_002975.2 |