Description / anti-human SCF-R monoclonal antibody
Stem cell factor receptor (CD117, the gene product of the c-kit proto-oncogene) and its ligand, stem cell factor, play essential roles in gametogenesis, melanogenesis and hematopoiesis. Stem cell factor receptor is a member of the type III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, Flt-3 and PDGF. It is expressed in hematopoietic progenitor cells, normal B and T cell progenitor cells, mast cells, germ cells, melanocytes, neurons, glial cells, placenta, kidney, lung and gut.
More Information
| Size | 50 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#14G5) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant protein of SCF-R extracellular domain (also called c-kit). |
| Antigen | recombinant human SCF-R EC domain |
| Application | WB, N |
| Synonyms | KIT, PBT; SCFR; C-Kit; CD117 |
| Uniprot ID | P10721 |
| Protein RefSeq | NP_000213.1 |
| mRNA RefSeq | NM_000222.2 |