Description / human Resistin antagonist protein
Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins (monomeric peptide contains 11 cysteine residues) referred to as the RELM family, and is also described as ADSF (Adipose Tissue-Specific Secretory Factor) or FIZZ3 (Found in Inflammatory Zone 3). Human resistin antagonist is a monomeric C7A mutant that does not form covalent dimers. It is expressed and purified by chromatographic techniques.
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| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The biological activity was evidenced by resistin antagonist activity to inhibit resistin-induced Akt phosphorylation in two cell lines. It also reduced the weight (mainly the visceral fat) and normalized GTT and ITT inHFD-fed mice. |
| N Terminal Sequence | ASSKTLA |
| Purity Confirmation | >98.0% as determined by RP-HPLC, SDS-PAGE Silver Stained and Gel filtration. |
| Length [aa] | 93 |
| Molecular Weight | 9.7 kDa |
| Species Reactivity | Mouse, Human |
| Formulation | lyophilized |
| Protein Sequence | ASSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP |
| Reconstitution | It is recommended to reconstitute the lyophilized resistin in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other buffered aqueous solutions containing carrier proteins. |
| Synonyms | Adipose tissue-specific secretory factor (ADSF), C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3 |
| Uniprot ID | Q9HD89 |
| Protein RefSeq | NP_065148 |
| mRNA RefSeq | NM_020415 |