Description / anti-human Resistin monoclonal antibody
Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant human Resistin is a 19.5 kDa disulfide-linked homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.
More Information
| Size | 500 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced in BALB/c mice using highly pure (>98%) recombinant human Resistin as the immunizing antigen. This IgG2bK antibody was purified from ascites fluid by Protein A affinity chromatography. |
| Antigen | Recombinant Human Resistin |
| Application | ELISA, WB |
| Synonyms | RETN; ADSF; RSTN; XCP1; FIZZ3; RETN1 |
| Uniprot ID | Q9HD89 |
| Protein RefSeq | NP_065148 |
| mRNA RefSeq | NM_020415 |