human Prolactin Receptor super active antagonist (del 1-9) G129R protein Human 2 µg
Description / human Prolactin Receptor super active antagonist (del 1-9) G129R protein
Prolactin Receptor (PRLR) belongs to the superfamily of class 1 cytokine receptors and binds Prolactin, also known as mammotrophin, luterotropic hormone, and lutetropin. Prolactin is a neuroendocrine hormone secreted by the pituitary gland, which primarily functions as stimulator for lactation during pregnancy and suckling but also acts as immune regulator by stimulating ornithine decarboxylase and protein kinase C activity. The Prolactin Receptor consists of at least three separate domains and varies in size (short and long forms) from 40 kDa to 100 kDa. The three domains include: an extracellular domain, transmembrane domain and a cytoplasmic region, with the extracellular domain containing the prolactin-binding site. Recombinant Human Prolactin Receptor Super Active Antagonist del 1-9 G129R mutant has a molecular weight of approx. 22 kDa, containing 190 amino acid residues with an additional N-terminal Alanin and was modified by additional 12 mutations.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to inhibit hPRL-induced proliferation of Nb2 cells or Baf3 cells stably transfected with hPRL receptors. It also interacts with the hPRL receptor extracellular domain at a 1:1 molar ratio as determined by SEC and SPR analysis. |
| Purity Confirmation | > 97% by SDS-PAGE & Gel Filtration |
| Length [aa] | 191 |
| Molecular Weight | 22 kDa |
| Species Reactivity | Rat, Human |
| Formulation | lyophilized |
| Reconstitution | It is recommended to reconstitute the lyophilized hPRL in sterile water or 0.4% NaHCO3 adjusted tp pH 8-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein. |
| Synonyms | Mammotropin, Luterotropic hormone, Lutetropin |
| Uniprot ID | P01236 |
| Protein RefSeq | NP_000939.1 |
| mRNA RefSeq | NM_000948 |