Description / human Prolactin, antagonist (del 1-9) G129R protein
Prolactin, also known as mammotrophin, luterotropic hormone, and lutetropin, is a neuroendocrine hormone secreted by the pituitary gland. Its primary function is to promote and maintain lactation during pregnancy and suckling. In addition, Prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. Recombinant human prolactin antagonist del 1-9 G129R mutant has a molecular weight of approx. 22 kDa and contains 190 amino acid residues with an additional N-terminal Alanin.
More Information
| Size | 1000 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to inhibit hPRL-induced proliferation of Nb2 cells or Baf3 cells stably transfected with hPRL receptors. It also interacts with the hPRL receptor extracellular domain at a 1:1 molar ratio as determined by SEC and SPR analysis. |
| Purity Confirmation | > 97% by SDS-PAGE & Gel Filtration |
| Length [aa] | 191 |
| Molecular Weight | 22 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Reconstitution | It is recommended to reconstitute the lyophilized hPRL in sterile water or 0.4% NaHCO3 adjusted tp pH 8-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein. |
| Synonyms | Mammotropin, Luterotropic hormone, Lutetropin, PLR |
| Uniprot ID | P01236 |
| Protein RefSeq | NP_000939.1 |
| mRNA RefSeq | NM_000948 |