Description / human NT-3 protein
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical
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| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 120 |
| Molecular Weight | 13.6 kDa |
| Species Reactivity | Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat Human, Monkey |
| Formulation | lyophilized |
| Protein Sequence | MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT |
| Synonyms | NTF3; NT3; HDNF; NGF2; NGF-2 |
| Uniprot ID | P20783 |
| Protein RefSeq | NP_001096124.1 |
| mRNA RefSeq | NM_001102654 |