Description / NP-1 (alpha-Defensin 1)
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins, which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
More Information
| Size | 100 µg |
|---|---|
| Source | Goat |
| Clone Nr. | Goat IgG |
| Length [aa] | 30 |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Protein Sequence | ACYCRIPACI AGERRYGTCI YQGRLWAFCC |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hNP-1. Anti-hNP-1 specific antibody was purified by affinity chromatography employing immobilized hNP-1 matrix. |
| Application | ELISA, WB, N |
| Synonyms | Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin |
| Uniprot ID | P59665 |
| Protein RefSeq | NP_004075 |
| mRNA RefSeq | NM_004084 |