Description / Myostatin
Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of Myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant human Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 109 |
| Molecular Weight | 25 kDa |
| Species Reactivity | Mouse, Rat, Human |
| Formulation | lyophilized |
| Protein Sequence | DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS |
| Synonyms | MSTN; GDF8; MSLHP |
| Uniprot ID | O14793 |
| Protein RefSeq | NP_005250.1 |
| mRNA RefSeq | NM_005259.2 |