Description / human Leptin protein
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues.
More Information
| Size | 1000 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and pla |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 147 |
| Molecular Weight | 16 kDa |
| Species Reactivity | Chicken, Monkey, Mouse, Rat, Human |
| Formulation | lyophilized |
| Protein Sequence | MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC |
| Synonyms | LEP; OB; OBS |
| Uniprot ID | P41159 |
| Protein RefSeq | NP_000221.1 |
| mRNA RefSeq | NM_000230 |