Description / anti-human Junctional adhesion molecule B (JAM-B) monoclonal antibody
Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculo-endothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#4L28) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of JAM-B (also called VE-JAM). |
| Antigen | recombinant human JAM-B |
| Application | WB, N |
| Synonyms | JAM2; JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43 |
| Uniprot ID | P57087 |
| Protein RefSeq | NP_067042.1 |
| mRNA RefSeq | NM_021219.3 |