Description / anti-human IL-4 receptor alpha monoclonal antibody
Two types of IL-4 receptor complexes have been described. The typeI IL-4 receptor complex is composed of a high-affinity IL-4-binding subunit (referred to as IL-4 R or IL-4 R alpha) and the common gamma chain that does not bind IL-4 by itself. The type II IL-4 receptor complex is composed of IL-4 R and IL-13 R alpha 1. Besides IL-4 signals, the type II IL-4 receptor complex can also transduce IL-13 signals. In the type II complex, IL-4 R subunit binds only IL-4 and not IL-13. Similarly, the IL-13 R alpha 1 subunit binds only IL-13 and not IL-4.
More Information
| Size | 50 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#4Y44) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Antigen | Human recombinant IL-4R alpha EC domain |
| Application | WB, IHC (P), N |
| Synonyms | Il4ra; Il4r; CD124 |
| Uniprot ID | P24394 |
| Protein RefSeq | NP_000409.1 |
| mRNA RefSeq | NM_000418 |