Description / anti-human IL-4 receptor alpha, soluble polyclonal antibody
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains, in addition to the γc, an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE.
More Information
| Size | 100 µg |
|---|---|
| Source | Rabbit |
| Isotype | Rabbit IgG |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Anti-Human sIL-4 Receptor α-specific antibody was purified by affinity chromatography employing an immobilized-Human sIL-4 Receptor α matrix. |
| Antigen | CHO cells derived Recombinant Human IL-4 Receptor α |
| Application | WB, ELISA |
| Synonyms | soluble Interleukin-4Rα, soluble IL-4 Receptor alpha, CD124 |
| Uniprot ID | P24394 |
| Protein RefSeq | NP_000409.1 |
| mRNA RefSeq | NM_000418 |