Description / mouse IL-31 protein
IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8 kDa protein containing 140 amino acid residues.
More Information
| Size | 500 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Testing in progress. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 140 |
| Molecular Weight | 15.8 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C |
| Synonyms | Il31; 1700013B14Rik |
| Uniprot ID | Q6EAL8 |
| Protein RefSeq | NP_083870.1 |
| mRNA RefSeq | NM_029594 |