Description / anti-human IL-31 polyclonal antibody
Interleukin 31 (IL-31) is a secreted, T-cell-derived, 24- kDa, short-chain member of the alpha-helical family of cytokines. The mature region is 141 amino acids (aa) in length and exhibits four alpha-helices. Human and mouse IL-31 are highly divergent at 24% aa sequence identity. The receptor for IL-31 is found on keratinocytes and monocytes. It is a heterodimer composed of the Oncostatin M receptor and a novel gp130-related molecule. IL-31 may be involved in pruritis, or skin itching.
More Information
| Size | 100 µg |
|---|---|
| Source | Rabbit |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant human IL-31. Anti-Human IL-31 specific antibody was purified by affinity chromatography employing immobilized human IL-31 matrix. |
| Antigen | Recombinant human IL-31 |
| Application | ELISA, WB |
| Synonyms | IL31; IL-31 |
| Uniprot ID | Q6EBC2 |
| Protein RefSeq | NP_001014358.1 |
| mRNA RefSeq | NM_001014336.1 |