Description / anti-human IL-3 receptor alpha monoclonal antibody
Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
More Information
| Size | 50 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#11A23) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human recombinant protein of IL-3R alpha extracellular domain. The IgG1 fraction of the culture supernatant was purified by Protein A/ |
| Antigen | recombinant human IL-3 receptor alpha extracellular domain |
| Application | IHC, WB, N |
| Synonyms | IL-3 R alpha, IL3ra |
| Uniprot ID | P26951 |
| Protein RefSeq | NO_01254642.1 |
| mRNA RefSeq | NM_001267713.1 |