Description / human IL-24 protein (His-Tag)
IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
More Information
| Size | 5 µg |
|---|---|
| Source | CHO cells |
| Biological Activity | Testing in progress. |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 161 |
| Molecular Weight | 18.9 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVLQNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA NNFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTKALG EVDILLTWMQ KFYKLHHHHH H |
| Synonyms | interleukin 24; C49A; FISP; MDA7; MOB5; ST16; IL10B |
| Uniprot ID | Q13007 |
| Protein RefSeq | NP_006841.1 |
| mRNA RefSeq | NM_006850.3 |