Description / human IL-22 protein
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 147 amino acid polypeptide chains.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Assay #1: Determined by its ability to stimulate the proliferation of HEK-Blue™ IL-22 reporter cells. Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 0.7- 1.0 ng/m |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 147 |
| Molecular Weight | 33.6 kDa |
| Species Reactivity | Monkey, Human |
| Formulation | lyophilized |
| Protein Sequence | MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI |
| Synonyms | Interleukin-22, IL-TIF, Cytokine ZCYTO18 |
| Uniprot ID | Q9GZX6 |
| Protein RefSeq | NP_065386.1 |
| mRNA RefSeq | NM_020525.4 |