Description / anti-human IL-1F6 monoclonal antibody
The IL-1 family of cytokines is a set of structurally related molecules that are primary mediators of inflammation. This family now consists of 11 cytokines and 9 cell-surface receptors, the best characterized of which are IL-1α, IL-1β, IL-1 receptor antagonist (IL-1ra), and IL-18. Seven novel members were recently identified from DNA databases almost simultaneously by several different groups, and to reduce confusion, a systematic nomenclature was proposed. IL-1F6, IL-1F8, and IL-1F9 have all reported proinflammatory properties. IL-1F5 shares 52% amino acid similarity with IL-1ra and as such antagonizes IL-1F6 and IL-1F9 at the IL-1R3(RAcP)–IL-1R6(Rrp2) receptor complex. IL-1F7 acts as an attenuator of IL-18 activity and may act as an inhibitor of innate immune signaling.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#3C55) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-1F6. |
| Antigen | recombinant human IL-1F6 |
| Application | WB |
| Synonyms | IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON) |
| Uniprot ID | Q9UHA7 |
| Protein RefSeq | NP_055255.1 |
| mRNA RefSeq | NM_014440.1 |