Description / human IL-19 protein
IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-alpha. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to activate STAT following receptor-ligand interaction. |
| Purity Confirmation | > 99% by SDS-PAGE & HPLC analysis |
| Length [aa] | 153 |
| Molecular Weight | 17.9 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA |
| Synonyms | IL19; MDA1; NG.1; ZMDA1; IL-10C |
| Uniprot ID | Q9UHD0 |
| Protein RefSeq | NP_715639.1 |
| mRNA RefSeq | NM_153758 |