Description / human IL-17B protein
IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.
More Information
| Size | 25 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 161 |
| Molecular Weight | 36.6 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F |
| Synonyms | IL17B; NIRF; IL-20; IL-17B; ZCYTO7 |
| Uniprot ID | Q9UHF5 |
| Protein RefSeq | NP_055258.1 |
| mRNA RefSeq | NM_014443 |