Description / rat IL-15 protein
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues.
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| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 as determined by the dose-dependant stimulation of the proliferation of murine CTLL-2 cells is < 10 ng/ml, corresponding to a specific activity of > 1 x 105 units/mg. |
| Purity Confirmation | > 96% by SDS-PAGE & HPLC analyses |
| Length [aa] | 115 |
| Molecular Weight | 13.5 kDa |
| Species Reactivity | Human, Mouse, Rat |
| Formulation | lyophilized |
| Protein Sequence | MNWIDVRYDL EKIESLIQFI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VIESGCKECE ELEERNFTEF LQSFIHIVQM FINTS |
| Synonyms | Il15; 19q11 |
| Uniprot ID | P97604 |
| Protein RefSeq | NP_037261.1 |
| mRNA RefSeq | NM_013129 |