Description / anti-human IL-12 receptor beta1 monoclonal antibody
The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#7V24) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-12R b1 extracellular domain. |
| Antigen | recombinant human IL-12R alpha 1 EC domain |
| Application | FC |
| Synonyms | IL12RB1; CD212; IL12RB; IL-12R-BETA1 |
| Uniprot ID | P42701 |
| Protein RefSeq | NP_005526.1 |
| mRNA RefSeq | NM_005535.1 |