Description / anti-mouse IL-1 R1 monoclonal antibody
IL-1 receptor type I (IL1R-I) is an 80 kD transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R-I binds the mature forms of IL-1α, IL-1β, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#11B7) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant extracellular domain of mouse IL-1 R1 protein. IgG2 fraction of the tissue culture supernatant was purified by Protein G affini |
| Antigen | extracellular domain of mouse IL1R-I |
| Application | WB |
| Synonyms | Il1r1; IL-iR; CD121a; CD121b; Il1r-1; Interleukin 1 receptor 1 |
| Uniprot ID | P13504 |
| Protein RefSeq | NP_032388.1 |
| mRNA RefSeq | NM_008362.2 |