Description / human IGF-BP2 protein
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
More Information
| Size | 5 µg |
|---|---|
| Source | Insect cells |
| Biological Activity | Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 289 |
| Molecular Weight | 31.5 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YN |
| Synonyms | IGFBP2; IBP2; IGF-BP53 |
| Uniprot ID | P18065 |
| Protein RefSeq | NP_000588.2 |
| mRNA RefSeq | NM_000597 |