Description / anti-human HCC-1 polyclonal antibody
HCC-1 or CCL14 is a chemokine that promotes chemotaxis of T cells, monocytes, and eosinophils. It occurs in two isoforms resulting from differential mRNA splicing. Following cleavage of a 19 amino acid signal peptide, mature CCL14a (aa 20-93) is a 74 amino acid peptide that is also known as HCC1 (Hemofiltrate CC Chemokine1). It is a weak CCR1 agonist, however, an 8 amino acid N-terminal truncation (aa 28-93) allows potent signaling through CCR1 and CCR5. CCL14b, also known as HCC3, is a 90 amino acid peptide (aa 20-109) resulting from the insertion of 16 amino acids between residues 7 and 8 of CCL14a.
More Information
| Size | 100 µg |
|---|---|
| Source | Rabbit |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant GDF-3. Anti-Human GDF-3 specific antibody was purified by affinity chromatography employing immobilized GDF-3 matrix. |
| Antigen | Recombinant human HCC-1 |
| Application | ELISA, WB |
| Synonyms | CCL14; CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3 |
| Uniprot ID | Q16627 |
| Protein RefSeq | NP_116739 |
| mRNA RefSeq | NM_032963 |