Description / human GDF-15/MIC-1 protein
GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.
More Information
| Size | 500 µg |
|---|---|
| Source | CHO cells |
| Biological Activity | Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osteoblast cells. The expected-ED50 for this effect is 75-200 ng/mL. |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 112 |
| Molecular Weight | 24.6 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI |
| Synonyms | Macrophage Inhibitory Cytokine 1, GDF15, PDF, MIC1, PLAB, MIC-1, NAG-1, PTGFB, GDF-15 |
| Uniprot ID | Q99988 |
| Protein RefSeq | NP_004855.3 |
| mRNA RefSeq | NM_004865 |