FRP-1, soluble Human 20 µg

In stock

Cat-Nr.
S01-070
Size
20 µg
  €221.00

Description / FRP-1, soluble

Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.

More Information

Size 20 µg
Source HeLa cells
Biological Activity Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3–0.5 μg/ml.
Purity Confirmation > 97% by SDS-PAGE & HPLC analyses
Length [aa] 283
Molecular Weight 32.5 kDa
Species Reactivity Mouse
Formulation lyophilized
Protein Sequence SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DN
Synonyms soluble Frizzled Related Protein-1, Secreted Apoptosis Related protein-2, SARP-2
Uniprot ID Q8N474
Protein RefSeq NP_003003.3
mRNA RefSeq NM_003012.4

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