Description / anti-mouse FGFR-3 monoclonal antibody
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N terminal signal peptide, three immunoglobulin (Ig)like domains, an acid box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine kinase domain.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#7M13) |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Antigen | Mouse recombinant protein FGF R3 |
| Application | N/B |
| Synonyms | Fibroblast growth factor receptor 3, FGFR-3, Heparin-binding growth factor receptor, CD333 |
| Uniprot ID | Q61851 |
| Protein RefSeq | NP_001156687.1 |
| mRNA RefSeq | NM_001359036.1 |