Description / mouse FGF acidic protein
FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant mouse FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.
More Information
| Size | 10 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by 3T3 cells in the presence of heparin is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg). Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 141 |
| Molecular Weight | 15.9 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D |
| Synonyms | HBGF-1; aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic); heparin-binding growth factor 1 |
| Uniprot ID | P61148 |
| Protein RefSeq | NP_034327.1 |
| mRNA RefSeq | NM_010197.3 |