Description / FGF acidic
FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant human FGF-acidic is a 15.8 kDa protein consisting of 140 amino acid residues.
More Information
| Size | 10 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 10 ng/ml. Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.5 ng/ml in the prese |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 141 |
| Molecular Weight | 15.8 kDa |
| Species Reactivity | Cow, Mouse, PIG, Rat, Human, Hamster, Leech |
| Formulation | lyophilized |
| Buffer | 5mM Sodium Phosphate, pH 8.0 + 100mM NaCl |
| Protein Sequence | MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D |
| Synonyms | FGF2; BFGF; FGFB; HBGF-2 |
| Uniprot ID | P05230 |
| Protein RefSeq | NP_000791.1 |
| mRNA RefSeq | NM_000800.4 |