Description / FGF-6
FGF-6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.
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Size | 5 µg |
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Source | E. coli |
Biological Activity | The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. |
Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
Length [aa] | 168 |
Molecular Weight | 18.7 kDa |
Species Reactivity | Human |
Formulation | lyophilized |
Buffer | 10 mM NaP, pH 7.2 + 50 mM NaCl |
Protein Sequence | GTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI |
Synonyms | FGF6; HST2; HBGF-6 |
Uniprot ID | P10767 |
Protein RefSeq | NP_066276 |
mRNA RefSeq | NM_020996 |