Description / human FGF-18 (Animal Free) protein
FGF-18 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-18 derived from E.coli is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from C-terminal truncation of the full length protein.
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| Size | 1000 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg. |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 173 |
| Molecular Weight | 20.1 kDa |
| Species Reactivity | Mouse, Rat, Human |
| Formulation | lyophilized |
| Protein Sequence | AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR |
| Synonyms | FGF18; ZFGF5; FGF-18 |
| Uniprot ID | O76093 |
| Protein RefSeq | NP_003853.1 |
| mRNA RefSeq | NM_003862 |