Description / human FGF-18 protein
FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant E.coli derived human FGF-18 is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from c-terminal truncation of the full length protein.
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| Size | 500 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg). |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 173 |
| Molecular Weight | 20.1 kDa |
| Species Reactivity | Mouse, Rat, Human |
| Formulation | lyophilized |
| Protein Sequence | AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR |
| Synonyms | FGF18; ZFGF5; FGF-18 |
| Uniprot ID | O76093 |
| Protein RefSeq | NP_003853.1 |
| mRNA RefSeq | NM_003862 |