Description / anti-mouse Fetuin-A monoclonal antibody
Mouse Fetuin A, also known as α2-Heremans-Schmid glycoprotein, is encoded by the AHSG gene. It has been also called "countertrypsin" because of its ability to inhibit trypsin. It is a major plasma protein and a member of the cystatin superfamily of protease inhibitors. It is expressed by hepatocytes, the principal cell source, and by monocyte/macrophages. The major form of plasma Fetuin A corresponds to two disulfide bondlinked chains derived from the single chain. FetuinA has a number of functions. It is a negative acutephase protein with normal circulating levels in adults (300-600 μg/mL), which fall significantly (30-50%) during injury and infection. It enhances entry of cationic inhibitors into macrophages. It inhibits both insulin receptor autophosphorylation and undesirable calcification.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#4N42) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Fetuin-A. |
| Antigen | recombinant mouse Fetuin-A |
| Application | WB |
| Synonyms | Ahsg; fetuin-A |
| Uniprot ID | P29699 |
| Protein RefSeq | NP_038493.1 |
| mRNA RefSeq | NM_013465.2 |