Description / Epigen
Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.
More Information
| Size | 25 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml. |
| Purity Confirmation | 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 72 |
| Molecular Weight | 7.9 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA |
| Synonyms | EPGN; EPG; epigen; PRO9904; ALGV3072 |
| Uniprot ID | Q6UW88 |
| Protein RefSeq | NP_001257922.1 |
| mRNA RefSeq | NM_001270993.1 |