Eotaxin-2 Anti-Human 500 µg

In stock

Cat-Nr.
101-M01
Size
500 µg
  €221.00

Description / Eotaxin-2

Eotaxin2, also named MPIF-2 and Ckβ6, is a CC chemokine that is designated CCL24. Eotaxin2 cDNA encodes a 10.5 kDa, 119 amino acid residue precursor protein with a 26 aa residue signal peptide that is cleaved to generate a mature protein predicted to contain 93 amino acid residues with an N-glycosylation site. C-terminally truncated variants with 78, 73, 75 and 76 residues have also been described. Eotaxin 2 shares 40%, 42% and 39% amino acid sequence identity with other CC chemokines CCL7/MCP3, CCL3/MIP1α, and CCL11/Eotaxin, respectively. Eotaxin2 mRNA is weakly expressed in activated monocytes and T lymphocytes. Recombinant Eotaxin2 induces chemotaxis of eosinophils, basophils, and resting T lymphocytes, but not monocytes or activated T lymphocytes. Eotaxin2 also suppresses colony formation by high proliferative multipotential hematopoietic progenitors. On eosinophils, the effects of Eotaxin2, Eotaxin and CCL13/MCP4 are mediated by the receptor CCR3.

More Information

Size 500 µg
Source Mouse
Isotype IgG1, kappa
Species Reactivity Human
Formulation lyophilized from PBS
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and Storage The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Preparation Produced in BALB/c mice using highly pure recombinant Human Eotaxin-2 as the immunizing antigen. IgG1/K antibody was purified from ascites fluid by antigen affinity chromatography.
Antigen Recombinant Human Eotaxin-2 (CCL24)
Application ELISA, WB, IHC (P)
Synonyms CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24
Uniprot ID O00175
Protein RefSeq NP_002982.2
mRNA RefSeq NM_002991

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