Description / human ENA-78 (8-78aa) / (CXCL5) protein
ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemo attractant for neutrophils. The murine homolog of ENA-78 is called LIX. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.
More Information
| Size | 100 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml |
| Purity Confirmation | 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 71 |
| Molecular Weight | 7.8 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N |
| Synonyms | CXCL5; SCYB5; ENA-78 |
| Uniprot ID | P42830 |
| Protein RefSeq | NP_002985.1 |
| mRNA RefSeq | NM_002994.3 |