Description / anti-human Emilin-2 monoclonal antibody
Emilins (elastin microfibril interface located proteins) are extracellular matrix glycoproteins that localize to sites with proximity to elastin and microfibrils. They consist of an N-terminal cysteine-rich EMI domain and a conserved C-terminal gC1q-like domain. Emilin-1 is abundant in elastin-rich tissues such as blood vessels, skin, heart and lung. It influences placenta formation and initial organogenesis with a later role in interstitial connective tissue. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is likely involved in the process of elastogenesis. Multimerin-2 (also known as Emilin-3 or EndoGlyx-1) is expressed during embryonic development. Multimerin-1 (also known as Emilin-4) is expressed in platelets and the endothelium of blood vessels and may act as a carrier protein for platelet factor V. Emilin-5 is encoded by the Emilin-3 gene and is sometimes referred to as Emilin-3. It contains the N-terminal cysteine-rich EMI domain but lacks the C-terminal gC1q-like domain. Emilin-5 is expressed in human mesenchymal stem cells and plays an important role in skeletal development.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2, kappa |
| Biological Activity | Western Blot: Use 2-5 µg/ml |
| Clone Nr. | (#828B3B3) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% |
| Preparation | The IgG2b/kappa fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 μm filtered solution in phosphate-buffered saline (PBS). |
| Antigen | Recombinant gC1q domain of EMILIN2 |
| Application | WB |
| Synonyms | EMILIN2; FOAP-10; EMILIN-2 |
| Uniprot ID | Q9BXX0 |
| Protein RefSeq | NP_114437.2 |
| mRNA RefSeq | NM_032048.2 |