Description / Anti-Mouse E-Cadherin monoclonal antibody
E-Cadherin/Cadherin1, also known as Uvomorulin in the mouse and rat, is a 120 kDa member of the Cadherin family of cell surface glycoproteins that mediate cell adhesion. Mouse ECadherin shares 92% and 81% amino acid sequence identity with the rat and human proteins, respectively. It is a single-pass transmembrane protein that mediates calcium-dependent epithelial cell adhesion. E-Cadherin has five extracellular EC domains that form homophilic cis-clusters between adjacent epithelial cells and trans-clusters within the same cell. E-Cadherin clusters are critical components of adherens junctions between epithelial cells and act in the formation and maintenance of the epithelial cell barrier.
More Information
| Size | 50 µg |
|---|---|
| Source | Rat |
| Isotype | IgG1 |
| Clone Nr. | (#6N32) |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Antigen | Mouse recombinant protein E-cadherin |
| Application | E |
| Synonyms | Cadherin-1; ARC-1, Epithelial cadherin (E-cadherin), Uvomorulin |
| Uniprot ID | P09803 |
| Protein RefSeq | NP_033994.1. |
| mRNA RefSeq | NM_009864.3 |