Description / CYR61
CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
More Information
Size | 5 µg |
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Source | E. coli |
Biological Activity | Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml |
Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
Length [aa] | 357 |
Molecular Weight | 39.5 kDa |
Species Reactivity | Mouse, Human, Chicken |
Formulation | lyophilized |
Buffer | 10 mM Sodium Citrate, pH 3.0 + 50 mM NaCl |
Protein Sequence | MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DN |
Synonyms | CYR61; CCN1; GIG1; IGFBP10 |
Uniprot ID | O00622 |
Protein RefSeq | NP_001545.2 |
mRNA RefSeq | NM_001554 |