CYR61 Human 5 µg

In stock

Cat-Nr.
100-149S
Size
5 µg
  €112.00

Description / CYR61

CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

More Information

Size 5 µg
Source E. coli
Biological Activity Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml
Purity Confirmation > 95% by SDS-PAGE & HPLC analyses
Length [aa] 357
Molecular Weight 39.5 kDa
Species Reactivity Mouse, Human, Chicken
Formulation lyophilized
Buffer 10 mM Sodium Citrate, pH 3.0 + 50 mM NaCl
Protein Sequence MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DN
Synonyms CYR61; CCN1; GIG1; IGFBP10
Uniprot ID O00622
Protein RefSeq NP_001545.2
mRNA RefSeq NM_001554

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