CTGF Human 5 µg

In stock

Cat-Nr.
100-146S
Size
5 µg
  €112.00

Description / CTGF

CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF beta1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.2 kDa protein of 98 amino acid residues.

More Information

Size 5 µg
Source E. coli
Biological Activity Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 µg/ml.
Purity Confirmation > 95% by SDS-PAGE & HPLC analyses
Length [aa] 97
Molecular Weight 11.0 kDa
Species Reactivity Mouse, Rat, Human, Chicken
Formulation lyophilized
Protein Sequence GKKCIRTPKI SKPIKFELSG CTSMKTYRAK FCGVCTDGRC CTPHRTTTLP VEFKCPDGEV MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA
Synonyms CTGF; CCN2; NOV2; HCS24; IGFBP8
Uniprot ID P29279
Protein RefSeq NP_001892
mRNA RefSeq NM_001901

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