Description / anti-human CRP polyclonal antibody
C-Reactive Protein (CRP) is a member of the Pentraxin family of proteins that are characterized by a cyclic, non-covalent, pentameric structure. IL-6, IL-1 beta, and glucocorticoids induce hepatic C-Reactive Protein synthesis and release. In humans, C-Reactive Protein is a major acute phase protein, increasing by 1,000-fold within 24 to 48 hours of infection, inflammation or tissue damage. C-Reactive Protein exhibits calcium-dependent binding of its principle ligand, phosphocholine, a constituent of bacterial and fungal cell walls. Upon ligand binding, C-Reactive Protein initiates the activation of the complement cascade and binds Fc gamma RI (CD64) and Fc gamma RIIA (CD32a) on phagocytes to activate phagocytic responses. In mouse, C-Reactive Protein is expressed at very low levels and is not an acute phase reactant.
More Information
| Size | 100 µg |
|---|---|
| Source | Rabbit |
| Isotype | Rabbit IgG |
| Biological Activity | WB: 0.1-0.2 μg/ml |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Anti-Human CRP-specific antibody was purified by affinity chromatography employing an immobilized Human CRP matrix. |
| Antigen | E.coli-derived, 23.2 kDa Recombinant Human CRP |
| Application | WB, ELISA |
| Synonyms | CRP; PTX1 |
| Uniprot ID | P02741 |
| Protein RefSeq | NP_000558.2 |
| mRNA RefSeq | NM_000567.2 |